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Using gene copy flexibility to build adaptable synthetic microbial populations

Nature Microbiology, ISSN: 2058-5276, Vol: 9, Issue: 8, Page: 1916-1917
2024
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Article Description

Plasmid coupling creates heterogeneity in copy number and, therefore, expression across a microbial population. We demonstrate that plasmid-encoded fitness differences between individuals can then lead to adaptation of the population to specific environments and can promote both genetic stability and memory of past environmental exposures.

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