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Nonhuman primate models of human viral infections

Nature Reviews Immunology, ISSN: 1474-1741, Vol: 18, Issue: 6, Page: 390-404
2018
  • 172
    Citations
  • 0
    Usage
  • 226
    Captures
  • 220
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    172
  • Captures
    226
  • Mentions
    220
    • News Mentions
      219
      • News
        219
    • Blog Mentions
      1
      • Blog
        1

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Nature Reviews Immunology Contents June 2018 Volume 18 Number 6 pp 357-415

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Review Description

Humans have a close phylogenetic relationship with nonhuman primates (NHPs) and share many physiological parallels, such as highly similar immune systems, with them. Importantly, NHPs can be infected with many human or related simian viruses. In many cases, viruses replicate in the same cell types as in humans, and infections are often associated with the same pathologies. In addition, many reagents that are used to study the human immune response cross-react with NHP molecules. As such, NHPs are often used as models to study viral vaccine efficacy and antiviral therapeutic safety and efficacy and to understand aspects of viral pathogenesis. With several emerging viral infections becoming epidemic, NHPs are proving to be a very beneficial benchmark for investigating human viral infections.

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