Calcium signalling in T cells
Nature Reviews Immunology, ISSN: 1474-1741, Vol: 19, Issue: 3, Page: 154-169
2019
- 331Citations
- 566Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations331
- Citation Indexes330
- 330
- CrossRef231
- Patent Family Citations1
- Patent Families1
- Captures566
- Readers566
- 563
- Mentions1
- Blog Mentions1
- Blog1
Most Recent Blog
Is too much vitaminD bad for you?
I noticed DrK tweeted on this and suggested that I have a look. The implications are that a middling amount is beneficial, but too much vitamin D is bad for you because it affects calcium levels in T cells. This may be lapped-up, because no doctors would think that you should be eating vitamin D capsules like smarties (Sugar coated chocolate sweets). Of course one says No s**t Sherlock, we already
Review Description
Calcium (Ca ) signalling is of paramount importance to immunity. Regulated increases in cytosolic and organellar Ca concentrations in lymphocytes control complex and crucial effector functions such as metabolism, proliferation, differentiation, antibody and cytokine secretion and cytotoxicity. Altered Ca regulation in lymphocytes leads to various autoimmune, inflammatory and immunodeficiency syndromes. Several types of plasma membrane and organellar Ca -permeable channels are functional in T cells. They contribute highly localized spatial and temporal Ca microdomains that are required for achieving functional specificity. While the mechanistic details of these Ca microdomains are only beginning to emerge, it is evident that through crosstalk, synergy and feedback mechanisms, they fine-tune T cell signalling to match complex immune responses. In this article, we review the expression and function of various Ca -permeable channels in the plasma membrane, endoplasmic reticulum, mitochondria and endolysosomes of T cells and their role in shaping immunity and the pathogenesis of immune-mediated diseases.
Bibliographic Details
Springer Science and Business Media LLC
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