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Cellular senescence as a possible link between prostate diseases of the ageing male

Nature Reviews Urology, ISSN: 1759-4820, Vol: 18, Issue: 10, Page: 597-610
2021
  • 29
    Citations
  • 0
    Usage
  • 27
    Captures
  • 0
    Mentions
  • 125
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    29
  • Captures
    27
  • Social Media
    125
    • Shares, Likes & Comments
      125
      • Facebook
        125

Review Description

Senescent cells accumulate with age in all tissues. Although senescent cells undergo cell-cycle arrest, these cells remain metabolically active and their secretome — known as the senescence-associated secretory phenotype — is responsible for a systemic pro-inflammatory state, which contributes to an inflammatory microenvironment. Senescent cells can be found in the ageing prostate and the senescence-associated secretory phenotype and can be linked to BPH and prostate cancer. Indeed, a number of signalling pathways provide biological plausibility for the role of senescence in both BPH and prostate cancer, although proving causality is difficult. The theory of senescence as a mechanism for prostate disease has a number of clinical implications and could offer opportunities for targeting in the future.

Bibliographic Details

Fiard, Gaelle; Stavrinides, Vasilis; Chambers, Emma S; Heavey, Susan; Freeman, Alex; Ball, Rhys; Akbar, Arne N; Emberton, Mark

Springer Science and Business Media LLC

Medicine

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