Ribosome collisions induce mRNA cleavage and ribosome rescue in bacteria
Nature, ISSN: 1476-4687, Vol: 603, Issue: 7901, Page: 503-508
2022
- 52Citations
- 148Captures
- 4Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations52
- Citation Indexes52
- 52
- CrossRef9
- Captures148
- Readers148
- 148
- Mentions4
- News Mentions4
- News4
Most Recent News
Bacterial ribosomes: molecular collision activates protection mechanism
Ribosomes are vitally important for all living organisms. They translate the information stored in the messenger molecule mRNA into proteins. To do this, they bind
Article Description
Ribosome rescue pathways recycle stalled ribosomes and target problematic mRNAs and aborted proteins for degradation. In bacteria, it remains unclear how rescue pathways distinguish ribosomes stalled in the middle of a transcript from actively translating ribosomes. Here, using a genetic screen in Escherichia coli, we discovered a new rescue factor that has endonuclease activity. SmrB cleaves mRNAs upstream of stalled ribosomes, allowing the ribosome rescue factor tmRNA (which acts on truncated mRNAs) to rescue upstream ribosomes. SmrB is recruited to ribosomes and is activated by collisions. Cryo-electron microscopy structures of collided disomes from E. coli and Bacillus subtilis show distinct and conserved arrangements of individual ribosomes and the composite SmrB-binding site. These findings reveal the underlying mechanisms by which ribosome collisions trigger ribosome rescue in bacteria.
Bibliographic Details
Springer Science and Business Media LLC
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