PlumX Metrics
Embed PlumX Metrics

Metabolic exhaustion in infection, cancer and autoimmunity review-article

Nature Immunology, ISSN: 1529-2916, Vol: 19, Issue: 3, Page: 213-221
2018
  • 83
    Citations
  • 0
    Usage
  • 274
    Captures
  • 1
    Mentions
  • 38
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    83
  • Captures
    274
  • Mentions
    1
    • Blog Mentions
      1
      • Blog
        1
  • Social Media
    38
    • Shares, Likes & Comments
      38
      • Facebook
        38

Review Description

It has become increasingly clear that changes in metabolism are not just consequences of T cell activation but instead are also essential drivers of that process that shape the extent and nature of differentiation and function. The process of T cell exhaustion has been linked to the outcome of chronic immune responses in multiple contexts, including chronic infection, cancer and autoimmunity. Factors that regulate the development and maintenance of exhaustion are of increasing interest as targets of therapeutic modulation. Studies have shown T cell immunometabolism to be integral to the control and development of T cell exhaustion. Early metabolic changes are responsible for the later emergence of exhaustion, do not simply reflect changes secondary to chronic activation and are modifiable. Increased understanding of this metabolic control promises to improve the ability to modulate T cell immunity to chronic antigen stimulation in multiple contexts.

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know