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Hippocampal spatio-predictive cognitive maps adaptively guide reward generalization

Nature Neuroscience, ISSN: 1546-1726, Vol: 26, Issue: 4, Page: 615-626
2023
  • 18
    Citations
  • 0
    Usage
  • 138
    Captures
  • 4
    Mentions
  • 1
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    18
  • Captures
    138
  • Mentions
    4
    • News Mentions
      3
      • News
        3
    • Blog Mentions
      1
      • Blog
        1
  • Social Media
    1
    • Shares, Likes & Comments
      1
      • Facebook
        1

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Human hippocampal and entorhinal neurons encode the temporal structure of experience

Nature, Published online: 25 September 2024; doi:10.1038/s41586-024-07973-1 Single-neuron recordings from intracranial electrodes inserted into human brains for clinical reasons suggest that the temporal structure of human experience is encoded in human hippocampal and entorhinal neurons.

Article Description

The brain forms cognitive maps of relational knowledge—an organizing principle thought to underlie our ability to generalize and make inferences. However, how can a relevant map be selected in situations where a stimulus is embedded in multiple relational structures? Here, we find that both spatial and predictive cognitive maps influence generalization in a choice task, where spatial location determines reward magnitude. Mirroring behavior, the hippocampus not only builds a map of spatial relationships but also encodes the experienced transition structure. As the task progresses, participants’ choices become more influenced by spatial relationships, reflected in a strengthening of the spatial map and a weakening of the predictive map. This change is driven by orbitofrontal cortex, which represents the degree to which an outcome is consistent with the spatial rather than the predictive map and updates hippocampal representations accordingly. Taken together, this demonstrates how hippocampal cognitive maps are used and updated flexibly for inference.

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