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Combination of polyetherketoneketone scaffold and human mesenchymal stem cells from temporomandibular joint synovial fluid enhances bone regeneration

Scientific Reports, ISSN: 2045-2322, Vol: 9, Issue: 1, Page: 472
2019
  • 37
    Citations
  • 0
    Usage
  • 87
    Captures
  • 7
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    37
    • Citation Indexes
      37
  • Captures
    87
  • Mentions
    7
    • News Mentions
      7
      • News
        7

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Researchers use PEKK implants to accelerate bone regeneration

We have often reported on the advantages of high-performance materials such as PEEK, ULTEM or PEKK . Particularly in the medical field, some of these

Article Description

Therapies using human mesenchymal stem cells (MSCs) combined with three-dimensional (3D) printed scaffolds are a promising strategy for bone grafting. But the harvest of MSCs still remains invasive for patients. Human synovial fluid MSCs (hSF-MSCs), which can be obtained by a minimally invasive needle-aspiration procedure, have been used for cartilage repair. However, little is known of hSF-MSCs in bone regeneration. Polyetherketoneketone (PEKK) is an attractive bone scaffold due to its mechanical properties comparable to bone. In this study, 3D-printed PEKK scaffolds were fabricated using laser sintering technique. hSF-MSCs were characterized and cultured on PEKK to evaluate their cell attachment, proliferation, and osteogenic potential. Rabbit calvarial critical-sized bone defects were created to test the bone regenerative effect of PEKK with hSF-MSCs. In vitro results showed that hSF-MSCs attached, proliferated, and were osteogenic on PEKK. In vivo results indicated that PEKK seeded with hSF-MSCs regenerated twice the amount of newly formed bone when compared to PEKK seeded with osteogenically-induced hSF-MSCs or PEKK scaffolds alone. These results suggested that there was no need to induce hSF-MSCs into osteoblasts prior to their transplantations in vivo. In conclusion, the combined use of PEKK and hSF-MSCs was effective in regenerating critical-sized bone defects.

Bibliographic Details

Lin, Yi; Umebayashi, Mayumi; Abdallah, Mohamed-Nur; Dong, Guoying; Roskies, Michael G; Zhao, Yaoyao Fiona; Murshed, Monzur; Zhang, Zhiguang; Tran, Simon D

Springer Science and Business Media LLC

Multidisciplinary

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