A two-sample Mendelian randomization analysis of modifiable risk factors and intracranial aneurysms
Scientific Reports, ISSN: 2045-2322, Vol: 12, Issue: 1, Page: 7659
2022
- 14Citations
- 16Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations14
- Citation Indexes14
- 14
- Captures16
- Readers16
- 16
- Mentions1
- News Mentions1
- News1
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Article Description
We aimed to investigate the causality between potentially modifiable risk factors and the risk of intracranial aneurysm. Genetic instruments for 51 modifiable factors and intracranial aneurysm data were obtained from recently published genome-wide association studies. We applied two-sample Mendelian randomization methods to investigate their causal relationships. Genetically predicted cigarettes per day, smoking initiation, systolic blood pressure, hypertension and body fat percentage were significantly associated with an increased risk of intracranial aneurysm [odds ratios (OR) 2.67, 95% confidence interval (CI) 1.75–4.07, p = 5.36 × 10, OR 1.53, 95% CI 1.32–1.77, p = 9.58 × 10, OR 1.05, 95% CI 1.02–1.08, p = 1.18 × 10, OR 1.65, 95% CI 1.19–2.28, p = 2.56 × 10 and OR 1.29, 95% CI 1.11–1.52, p = 1.33 × 10, respectively]. Type 2 diabetes mellitus was significantly associated with a decreased risk of intracranial aneurysm (OR 0.89, 95% CI 0.83–0.95, p = 8.54 × 10). Body fat percentage was significantly associated with subarachnoid haemorrhage (p = 5.70 × 10). This study provided genetic evidence of causal effects of smoking, blood pressure, type 2 diabetes mellitus and obesity on the risk of intracranial aneurysm.
Bibliographic Details
Springer Science and Business Media LLC
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