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Pre-exposure cognitive performance variability is associated with severity of respiratory infection

Scientific Reports, ISSN: 2045-2322, Vol: 12, Issue: 1, Page: 22589
2022
  • 1
    Citations
  • 0
    Usage
  • 19
    Captures
  • 21
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    1
  • Captures
    19
  • Mentions
    21
    • News Mentions
      21
      • 21

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Predicting Disease Susceptibility Through Changes in Cognitive Performance

Cognitive function and other physiological factors, such as stress levels, have long been associated with physiological health and immunocompetence. Markers of cognitive function, such as

Article Description

Using data from a longitudinal viral challenge study, we find that the post-exposure viral shedding and symptom severity are associated with a novel measure of pre-exposure cognitive performance variability (CPV), defined before viral exposure occurs. Each individual’s CPV score is computed from data collected from a repeated NeuroCognitive Performance Test (NCPT) over a 3 day pre-exposure period. Of the 18 NCPT measures reported by the tests, 6 contribute materially to the CPV score, prospectively differentiating the high from the low shedders. Among these 6 are the 4 clinical measures digSym-time, digSym-correct, trail-time, and reaction-time, commonly used for assessing cognitive executive functioning. CPV is found to be correlated with stress and also with several genes previously reported to be associated with cognitive development and dysfunction. A perturbation study over the number and timing of NCPT sessions indicates that as few as 5 sessions is sufficient to maintain high association between the CPV score and viral shedding, as long as the timing of these sessions is balanced over the three pre-exposure days. Our results suggest that variations in cognitive function are closely related to immunity and susceptibility to severe infection. Further studying these relationships may help us better understand the links between neurocognitive and neuroimmune systems which is timely in this COVID-19 pandemic era.

Bibliographic Details

Zhai, Yaya; Doraiswamy, P Murali; Woods, Christopher W; Turner, Ronald B; Burke, Thomas W; Ginsburg, Geoffrey S; Hero, Alfred O

Springer Science and Business Media LLC

Multidisciplinary

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