PlumX Metrics
Embed PlumX Metrics

Class switch towards spike protein-specific IgG4 antibodies after SARS-CoV-2 mRNA vaccination depends on prior infection history

Scientific Reports, ISSN: 2045-2322, Vol: 13, Issue: 1, Page: 13166
2023
  • 20
    Citations
  • 0
    Usage
  • 38
    Captures
  • 4
    Mentions
  • 114
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    20
  • Captures
    38
  • Mentions
    4
    • Blog Mentions
      2
      • Blog
        2
    • News Mentions
      2
      • News
        2
  • Social Media
    114
    • Shares, Likes & Comments
      114
      • Facebook
        114

Most Recent News

New Findings from Semmelweis University Describe Advances in COVID-19 (Class switch towards spike protein-specific IgG4 antibodies after SARS-CoV-2 mRNA vaccination depends on prior infection history)

2023 AUG 30 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx COVID-19 Daily -- Investigators publish new report on COVID-19. According to news

Article Description

Vaccinations against SARS-CoV-2 reduce the risk of developing serious COVID-19 disease. Monitoring spike-specific IgG subclass levels after vaccinations may provide additional information on SARS-CoV-2 specific humoral immune response. Here, we examined the presence and levels of spike-specific IgG antibody subclasses in health-care coworkers vaccinated with vector- (Sputnik, AstraZeneca) or mRNA-based (Pfizer-BioNTech, Moderna) vaccines against SARS-CoV-2 and in unvaccinated COVID-19 patients. We found that vector-based vaccines elicited lower total spike-specific IgG levels than mRNA vaccines. The pattern of spike-specific IgG subclasses in individuals infected before mRNA vaccinations resembled that of vector-vaccinated subjects or unvaccinated COVID-19 patients. However, the pattern of mRNA-vaccinated individuals without SARS-CoV-2 preinfection showed a markedly different pattern. In addition to IgG1 and IgG3 subclasses presented in all groups, a switch towards distal IgG subclasses (spike-specific IgG4 and IgG2) appeared almost exclusively in individuals who received only mRNA vaccines or were infected after mRNA vaccinations. In these subjects, the magnitude of the spike-specific IgG4 response was comparable to that of the spike-specific IgG1 response. These data suggest that the priming of the immune system either by natural SARS-CoV-2 infection or by vector- or mRNA-based vaccinations has an important impact on the characteristics of the developed specific humoral immunity.

Bibliographic Details

Kiszel, Petra; Sík, Pál; Miklós, János; Kajdácsi, Erika; Sinkovits, György; Cervenak, László; Prohászka, Zoltán

Springer Science and Business Media LLC

Multidisciplinary

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know