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Identification of LncPVT1 and CircPVT1 as prognostic biomarkers in human colorectal polyps

Scientific Reports, ISSN: 2045-2322, Vol: 13, Issue: 1, Page: 13113
2023
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Data from Islamic Azad University Broaden Understanding of Biomarkers (Identification of LncPVT1 and CircPVT1 as prognostic biomarkers in human colorectal polyps)

2023 AUG 25 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Daily -- Investigators publish new report on biomarkers. According to news reporting

Article Description

LncPVT1 and CircPVT1 are isoforms for the PVT1 gene and are associated with cancer progression and carcinogenesis. Our study investigated the expression of LncPVT1 and CircPVT1 in colon adenoma polyps. 40 tissues of colorectal polyps and 40 normal-adjacent tissues (NATs) were taken. The expression of LncPVT1 and CircPVT1 was evaluated through qRael-Time PCR. The relation between expression and features of clinicopathological was explored. The ceRNA network was constructed by LncPVT1 and CircPVT1 and predicted miRNAs and miRNAs targets. Further, hub nodes in this network were determined using the cytoHubba package. Over-expressed LncPVT1 and CircPVT1 were differentiated in polyp and NATs. The expression level of LncPVT1 and CircPVT1 were significantly higher in adenoma polyps than in hyperplastic polyps. The area under the curve of the ROC estimate for the LncPVT1 and CircPVT1 was 0.74 and 0.77, respectively. A positive correlation was observed between the LncPVT1 expression and CircPVT1. Three miRNAs, including hsa-miR-484, hsa-miR-24-3p, hsa-miR-423-5p, and CircPVT1, were detected as ceRNA hub nodes. In this study, expression profiles of LncPVT1 and CircPVT1 were significantly higher in precancerous polyps. In addition, based on our in silico analysis, LncPVT1, CircPVT1/miR-484, miR-24-3p, miR-423-5p/PLAGL2 axis might be involved in colon cancer development. LncPVT1 and CircPVT1 can be prescribed as warning problems as potential prognostic biomarkers in patients with pre-CRC colon polyps.

Bibliographic Details

RezaSoltani, Mahsa; Forouzesh, Flora; Salehi, Zahra; Zabihi, Mohammad-Reza; Rejali, Leili; Nazemalhosseini-Mojarad, Ehsan

Springer Science and Business Media LLC

Multidisciplinary

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