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Quantitative evaluation of rat sciatic nerve degeneration using high-frequency ultrasound

Scientific Reports, ISSN: 2045-2322, Vol: 13, Issue: 1, Page: 20228
2023
  • 1
    Citations
  • 0
    Usage
  • 5
    Captures
  • 1
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    1
  • Captures
    5
  • Mentions
    1
    • News Mentions
      1
      • 1

Most Recent News

Researchers from University of California Provide Details of New Studies and Findings in the Area of Nerve Degeneration (Quantitative evaluation of rat sciatic nerve degeneration using high-frequency ultrasound)

2023 NOV 01 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Daily -- Investigators discuss new findings in nerve degeneration. According

Article Description

In this study, we evaluated the utility of using high-frequency ultrasound to non-invasively track the degenerative process in a rat model of peripheral nerve injury. Primary analyses explored spatial and temporal changes in quantitative backscatter coefficient (BSC) spectrum-based outcomes and B-mode textural outcomes, using gray level co-occurrence matrices (GLCMs), during the progressive transition from acute to chronic injury. As secondary analyses, correlations among GLCM and BSC spectrum-based parameters were evaluated, and immunohistochemistry were used to suggest a structural basis for ultrasound outcomes. Both mean BSC spectrum-based and mean GLCM-based measures exhibited significant spatial differences across presurgical and 1-month/2-month time points, distal stumps enclosed proximity to the injury site being particularly affected. The two sets of parameters sensitively detected peripheral nerve degeneration at 1-month and 2-month post-injury, with area under the receiver operating charactersitic curve > 0.8 for most parameters. The results also indicated that the many BSC spectrum-based and GLCM-based parameters significantly correlate with each other, and suggested a common structural basis for a diverse set of quantitative ultrasound parameters. The findings of this study suggest that BSC spectrum-based and GLCM-based analysis are promising non-invasive techniques for diagnosing peripheral nerve degeneration.

Bibliographic Details

Wu, Yuanshan; Barrere, Victor; Han, Aiguo; Andre, Michael P; Orozco, Elisabeth; Cheng, Xin; Chang, Eric Y; Shah, Sameer B

Springer Science and Business Media LLC

Multidisciplinary

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