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Schedule-dependent response of neuroblastoma cell lines to combinations of etoposide and cisplatin

British Journal of Cancer, ISSN: 0007-0920, Vol: 86, Issue: 3, Page: 485-489
2002
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Article Description

The growth inhibitory effects of cisplatin and etoposide on neuroblastoma cell lines were investigated in several scheduled combinations. Results were analyzed using median effect and combination index analyses. In all schedules in which cisplatin was administered prior to etoposide a synergistic effect was observed. Conversely, an antagonistic effect was seen in all schedules where etoposide was administered before cisplatin. © 2002 The Cancer Research Campaign.

Bibliographic Details

E. L. Meczes; A. D.J. Pearson; C. A. Austin; M. J. Tilby

Springer Science and Business Media LLC

Medicine; Biochemistry, Genetics and Molecular Biology

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