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Mutation of the PIK3CA oncogene in human cancers

British Journal of Cancer, ISSN: 0007-0920, Vol: 94, Issue: 4, Page: 455-459
2006
  • 423
    Citations
  • 0
    Usage
  • 462
    Captures
  • 1
    Mentions
  • 20
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    423
  • Captures
    462
  • Mentions
    1
    • Blog Mentions
      1
      • Blog
        1
  • Social Media
    20
    • Shares, Likes & Comments
      20
      • Facebook
        20

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Article Description

It is now well established that cancer is a genetic disease and that somatic mutations of oncogenes and tumour suppressor genes are the initiators of the carcinogenic process. The phosphatidylinositol 3-kinase signalling pathway has previously been implicated in tumorigenesis, and evidence over the past year suggests a pivotal role for the phosphatidylinositol 3-kinase catalytic subunit, PIK3CA, in human cancers. In this review, we analyse recent reports describing PIK3CA mutations in a variety of human malignancies, and discuss their possible implications for diagnosis and therapy. © 2006 Cancer Research.

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