Clinical impact of MMP and TIMP gene polymorphisms in gastric cancer
British Journal of Cancer, ISSN: 0007-0920, Vol: 95, Issue: 6, Page: 744-751
2006
- 110Citations
- 29Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations110
- Citation Indexes110
- 110
- CrossRef85
- Captures29
- Readers29
- 29
Article Description
Gastric cancers express enhanced levels of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs). Single-nucleotide polymorphisms (SNPs) in MMP and TIMP genes may be associated with disease susceptibility and might also affect their antigen expression. We studied the genotype distribution and allele frequencies of SNPs of MMP-2, -7, -8 and -9 and TIMP-1 and -2 in gastric cancer patients in relation to tumour progression, patient survival and tissue antigen expression. The genotype distribution and allele frequencies were similar in gastric cancer patients and controls, except for MMP-7. In addition, the genotype distribution of MMP-7 was associated with Helicobacter pylori status (χ 7.8, P = 0.005) and tumour-related survival of the patients. Single-nucleotide polymorphism TIMP-2 correlated significantly with the WHO classification (χ 5.9, P = 0.03) and also strongly with tumour-related survival (log rank 11.74, P = 0.0006). Single-nucleotide polymorphisms of MMP-2, -8, -9 and TIMP-1 were not associated with tumour-related survival. Only the gene promoter MMP-2 polymorphism correlated significantly with the protein level within the tumours. First-order dendrogram cluster analysis combined with Cox analysis identified the MMP-7 and TIMP-2 polymorphism combination to have a major impact on patients survival outcome. We conclude that MMP-related SNPs, especially MMP-7 and TIMP-2, may be helpful in identifying gastric cancer patients with a poor clinical outcome. © 2006 Cancer Research UK.
Bibliographic Details
Springer Science and Business Media LLC
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