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GARDASIL®: Prophylactic human papillomavirus vaccine development - From bench top to bed-side

Clinical Pharmacology and Therapeutics, ISSN: 0009-9236, Vol: 81, Issue: 2, Page: 259-264
2007
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Article Description

GARDASIL® (Merck, Whitehouse Station, NJ) is a non-infectious recombinant, quadrivalent vaccine prepared from the highly purified virus-like particles (VLPs) of the major capsid proteins of human papillomavirus (HPV) types 6, 11, 16, and 18. GARDASIL® is the first vaccine approved for use in women aged 9-26 years for the prevention of cervical cancer and genital warts, as well as vulvar and vaginal precancerous lesions. This report describes some of the key preclinical efforts, achievements in pharmaceutical development, in vivo animal evaluation, and clinical trial data. © 2007 American Society for Clinical Pharmacology and Therapeutics.

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