Cloning of murine IL-22 receptor alpha 2 and comparison with its human counterpart
Genes and Immunity, ISSN: 1466-4879, Vol: 5, Issue: 5, Page: 330-336
2004
- 60Citations
- 29Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations60
- Citation Indexes57
- 57
- CrossRef48
- Patent Family Citations3
- Patent Families3
- Captures29
- Readers29
- 29
Article Description
We have identified the mouse and rat homologs of human interleukin-22 receptor alpha 2 (IL-22Rα2) and compared the localization, structure, and expression of the encoding murine and human genes. The mouse IL-22Rα2-encoding gene is located on chromosome 10A3 between, like in human, the genes for interferon-gamma R1 and IL-20R1. It spans a region of approximately 10 kb therefore being three times shorter than the human gene. Although the overall gene structure in both species is similar, the mouse gene lacks a counterpart to the third coding exon of the human gene known to be alternatively spliced. Like in human, mouse and rat IL-22Rα2 exist only as soluble receptors as deduced from the lack of transmembrane and intracellular domains encoding sequences. Quantitative expression analyses showed, analogically to the human system, a limited tissue distribution of mouse IL-22Rα2 mRNA. Differential modulation of IL-22Rα2 mRNA expression was observed upon systemic inflammation in mice in spleen, thymus, and lymph node. © 2004 Nature Publishing Group All rights reserved.
Bibliographic Details
Springer Science and Business Media LLC
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