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Tumor necrosis factor-α in cisplatin nephrotoxicity: A homebred foe?

Kidney International, ISSN: 0085-2538, Vol: 72, Issue: 1, Page: 5-7
2007
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Article Description

A robust inflammatory response involving tumor necrosis factor-α (TNFα) is induced during cisplatin nephrotoxicity. Using chimeric models, Reeves and colleagues now demonstrate that resident kidney cells, rather than infiltrating immune cells, are the major producers of TNF-α. Blockade of TNFα attenuates inflammation and associated kidney injury.

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