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Myb proteins regulate the expression of diverse target genes

Oncogene, ISSN: 0950-9232, Vol: 24, Issue: 8, Page: 1375-1384
2005
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Article Description

Hematopoiesis, the process by which mature blood cells arise, is controlled by multiple transcription factors, which act in stage- and lineage-specific complexes. It is a major goal to elucidate the genes regulated by these transcription factors, in order to obtain a full understanding of the process and its malignant counterpart, leukemia. Myb family transcription factors play a central role in hematopoiesis. To identify new Myb family target genes, we have used an inducible dominant-negative protein for a subtraction cloning protocol in a model cell system (FDCP-Mix) with many characteristics of normal hematopoiesis. We present here a novel group of 29 validated Myb family target genes of diverse functions. © 2005 Nature Publishing Group. All rights reserved.

Bibliographic Details

Lang, Georgina; White, Jonathan R; Argent-Katwala, Mary J G; Allinson, Christopher G; Weston, Kathleen

Springer Science and Business Media LLC

Biochemistry, Genetics and Molecular Biology

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