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Evaluation of vegf-c and tumor markers in bronchoalveolar lavage fluid for lung cancer diagnosis

Scientific Reports, ISSN: 2045-2322, Vol: 3, Issue: 1, Page: 3473
2013
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Article Description

A total of 87 patients were enrolled and bronchoalveolar lavage fluid (BALF) samples were obtained from all subjects. A significant difference was found in BALF VEGF-C level between patients with squamous cell carcinoma and benign diseases (P = 0.043). In addition, the concentration of NSE in BALF form the malignant group was significantly higher compared with that of the benign groups (P = 0.018). However, no statistical difference was observed in BALF CEA (P = 0.375) or CYFRA21-1 (P = 0.838) between lung cancer patients and nonmalignant controls. With a cut-off value of 2.06 ng/ml, NSE had a sensitivity of 72.9%, a specificity of 69.2%, respectively, in predicting the malignant nature of pulmonary mass. Our study observed that the level of VEGF-C was increased in BALF of patients with squamous cell carcinoma. Moreover, we found that NSE was significantly higher in BALF of lung cancer patients than in benign diseases.

Bibliographic Details

Cao, Chao; Chen, Zhong-Bo; Sun, Shi-Fang; Yu, Yi-Ming; Ding, Qun-Li; Deng, Zai-Chun

Springer Science and Business Media LLC

Multidisciplinary

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