A 'Clicked'tetrameric hydroxamic acid glycopeptidomimetic antagonizes sugar-lectin interactions on the cellular level
Scientific Reports, ISSN: 2045-2322, Vol: 4, Issue: 1, Page: 5513
2014
- 19Citations
- 6Captures
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Article Description
A tetrameric N-acetyl galactosaminyl (GalNAc) peptidomimetic was constructed by N-acetylation of repeating proline-based hydroxamic acid units, followed by a convergent 'click chemistry' coupling. This novel glycopeptidomimetic was determined to effectively antagonize the interaction between a transmembrane hepatic lectin and GalNAc on the cellular level.
Bibliographic Details
Springer Science and Business Media LLC
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