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Homologation of α-amino acids to β-amino acids using BocO

Journal of the Chemical Society. Perkin Transactions 1, ISSN: 1364-5463, Vol: 2, Issue: 18, Page: 2087-2089
2002
  • 18
    Citations
  • 0
    Usage
  • 10
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    18
    • Citation Indexes
      18
  • Captures
    10

Article Description

The use of BocO as a coupling agent in the homologation of N-urethane protected-α-amino acid to its β-homomers by the Arndt–Eistert method is described. The homologation gives good yields without racemization. The use of BocO as a coupling agent not only allows the easy scale up of the process but also it is cost effective. © 2002 The Royal Society of Chemistry.

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