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Stability and size dependence of protein microspheres prepared by ultrasonication

Journal of Materials Chemistry, ISSN: 0959-9428, Vol: 18, Issue: 42, Page: 5162-5166
2008
  • 40
    Citations
  • 0
    Usage
  • 25
    Captures
  • 0
    Mentions
  • 0
    Social Media
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Metrics Details

  • Citations
    40
    • Citation Indexes
      40
  • Captures
    25

Article Description

Protein microspheres have been prepared by sonicating oil in an aqueous protein solution. Such prepared microspheres can be used in magnetic resonance imaging (MRI), micro-encapsulation, and drug delivery systems. When they are used in the blood circulation, their size and stability become most important. In this paper, the factors affecting the size and size distribution of these microspheres are discussed and a way to control the size of the microspheres is put forward. Small microspheres with size less than 1 m were selected by gravitational sedimentation. The selected microspheres have a narrow size distribution and can be used in the blood circulation safely. The loading of dye into these microspheres was easily achieved by dissolution of drugs in the oil phase before sonication. The protein microspheres showed excellent protection for the loaded dye, which can be stably carried for several weeks. © 2008 The Royal Society of Chemistry.

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