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Hyperstable miniproteins: Additive effects of d- and l-Ala mutations

Organic and Biomolecular Chemistry, ISSN: 1477-0520, Vol: 6, Issue: 23, Page: 4287-4289
2008
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The folding enantioselectivity for d-Ala versusl-Ala at one glycine site in the Trp-cage is 16 kJ mol; judicious introductions of alanines of the correct chirality raises the melting temperature of this 20-residue fold to 83 °C. © 2008 The Royal Society of Chemistry.

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