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The UDP-Galp mutase catalyzed isomerization: Synthesis and evaluation of 1,4-anhydro-β-d-galactopyranose and its [2.2.2] methylene homologue

Organic and Biomolecular Chemistry, ISSN: 1477-0520, Vol: 8, Issue: 7, Page: 1596-1602
2010
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Article Description

The synthesis of 1,4-anhydro-β-d-galactopyranose (1,5-anhydro-α- d-galactofuranose), a proposed intermediate in the ring contraction isomerisation catalyzed by UDP-galactopyranose mutase, together with its [2.2.2] bicyclic methylene homologue, synthesised as a possible competitive inhibitor or alternative substrate, are reported. Neither compound was found to be an inhibitor or substrate for UDP-galactopyranose mutase from Klebsiella pneumoniae. © 2010 The Royal Society of Chemistry.

Bibliographic Details

Sadeghi-Khomami, Ali; Forcada, Tatiana J; Wilson, Claire; Sanders, David A R; Thomas, Neil R

Royal Society of Chemistry (RSC)

Biochemistry, Genetics and Molecular Biology; Chemistry

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