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Highly regio- and stereoselective synthesis of alkenylboronic esters by copper-catalyzed boron additions to disubstituted alkynes

Chemical Communications, ISSN: 1364-548X, Vol: 47, Issue: 10, Page: 2943-2945
2011
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The copper-catalyzed addition of bis(pinacolato)diboron to internal alkynes in the presence of methanol generates alkenylboron compounds with high levels of regio- and stereoselectivities. The catalytic efficiency is increased by using monodentate phosphine ligands, especially P(p-tolyl) and a range of internal alkynes was borylated in good yields. © 2012 Royal Society of Chemistry.

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