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Biological evaluation of imidazolium- and ammonium-based salts as HIV-1 integrase inhibitors

MedChemComm, ISSN: 2040-2503, Vol: 2, Issue: 2, Page: 143-150
2011
  • 19
    Citations
  • 0
    Usage
  • 12
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    19
    • Citation Indexes
      19
  • Captures
    12

Article Description

Ammonium- and imidazolium-based ionic salts were studied for their application as inhibitors of HIV-1 integrase (IN). These compounds were active in the inhibition of both the 3′-processing (3′-P) and strand transfer (ST) steps of the integration reaction. A correlation of activity with chain length of the alkyl substituent in both classes of ionic salts was observed. © 2011 The Royal Society of Chemistry.

Bibliographic Details

Kasthuraiah Maddali; Christophe Marchand; Yves Pommier; Vineet Kumar; Sanjay V. Malhotra

Royal Society of Chemistry (RSC)

Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics; Chemistry

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