Elaboration of vinblastine hybrids using a reactive in situ generated N-carboxyanhydride
Organic and Biomolecular Chemistry, ISSN: 1477-0520, Vol: 9, Issue: 13, Page: 4873-4881
2011
- 8Citations
- 5Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations8
- Citation Indexes8
- CrossRef6
- Captures5
- Readers5
Article Description
Hybrids of vinblastine and phomopsin, designed by a molecular modelling study, were elaborated in order to target tubulin. The key step of the synthesis (fragmentation and insertion of vindoline) was mediated by an internal N-carboxyanhydride (or O-acylcarbamate). This reaction was diastereospecific and addition of silver salts could reverse the diastereoselectivity. Even if the synthesized compounds are inactive, this synthesis represents an original example of a C-N fragmentation mediated by a N-carboxyanhydride. © The Royal Society of Chemistry 2011.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79959796963&origin=inward; http://dx.doi.org/10.1039/c0ob01065k; http://www.ncbi.nlm.nih.gov/pubmed/21607276; https://xlink.rsc.org/?DOI=c0ob01065k; https://dx.doi.org/10.1039/c0ob01065k; https://pubs.rsc.org/en/content/articlelanding/2011/ob/c0ob01065k
Royal Society of Chemistry (RSC)
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