Microfluidic baker's transformation device for three-dimensional rapid mixing
Lab on a Chip, ISSN: 1473-0189, Vol: 11, Issue: 19, Page: 3356-3360
2011
- 46Citations
- 47Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations46
- Citation Indexes46
- 46
- CrossRef43
- Captures47
- Readers47
- 47
Review Description
We developed a new passive-type micromixer based on the baker's transformation and realized a fast mixing of a protein solution, which has lower diffusion constant. The baker's transformation is an ideal mixing method, but there is no report on the microfluidic baker's transformation (MBT), since it is required to fabricate the complicated three-dimensional (3D) structure to realize the MBT device. In this note, we successfully fabricate the MBT device by using precision diamond cutting of an oxygen-free copper substrate for the mould fabrication and PDMS replication. The MBT device with 10.4 mm mixing length enables us to achieve complete mixing of a FITC solution (D = 2.6 × 10 m s) within 51 ms and an IgG solution (D = 4.6 × 10 m s) within 306 ms. Its mixing speed is 70-fold higher for a FITC solution and 900-fold higher for an IgG solution than the mixing speed by the microchannel without MBT structures. The Péclet number to attain complete mixing in the MBT device is estimated to be 6.9 × 10. © 2011 The Royal Society of Chemistry.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=80052533206&origin=inward; http://dx.doi.org/10.1039/c1lc20342h; http://www.ncbi.nlm.nih.gov/pubmed/21845274; https://xlink.rsc.org/?DOI=c1lc20342h; https://dx.doi.org/10.1039/c1lc20342h; https://pubs.rsc.org/en/content/articlelanding/2011/lc/c1lc20342h
Royal Society of Chemistry (RSC)
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