Entropy and Mg control ligand affinity and specificity in the malachite green binding RNA aptamer
Molecular BioSystems, ISSN: 1742-206X, Vol: 7, Issue: 7, Page: 2156-2163
2011
- 17Citations
- 44Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations17
- Citation Indexes17
- 17
- CrossRef13
- Captures44
- Readers44
- 44
Article Description
The binding of small molecule targets by RNA aptamers provides an excellent model to study the versatility of RNA function. The malachite green aptamer binds and recognizes its ligand via stacking and electrostatic interactions. The binding of the aptamer to its original selection target and three related molecules was determined by isothermal titration calorimetry, equilibrium dialysis, and fluorescence titration. The results reveal that the entropy of complex formation plays a large role in determining binding affinity and ligand specificity. These data combined with previous structural studies show that metal ions are required to stabilize the complexes with non-native ligands whereas the complex with the original selection target is stable at low salt and in the absence of divalent metal ions. © 2011 The Royal Society of Chemistry.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79959192255&origin=inward; http://dx.doi.org/10.1039/c1mb05075c; http://www.ncbi.nlm.nih.gov/pubmed/21523267; https://xlink.rsc.org/?DOI=c1mb05075c; https://dx.doi.org/10.1039/c1mb05075c; https://pubs.rsc.org/en/content/articlelanding/2011/mb/c1mb05075c
Royal Society of Chemistry (RSC)
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