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Design, synthesis, and structure-activity relationships of 1,3,4-oxadiazol-2(3H)-ones as novel FAAH inhibitors

MedChemComm, ISSN: 2040-2503, Vol: 2, Issue: 9, Page: 889-894
2011
  • 18
    Citations
  • 0
    Usage
  • 15
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    18
    • Citation Indexes
      18
  • Captures
    15

Article Description

Novel 5-aryloxy substituted 3-phenyl-1,3,4-oxadiazol-2(3H)-ones were prepared and identified as potent inhibitors of FAAH. In vitro SAR are discussed. Structural variations of the selected lead compound were explored in order to optimise in vivo efficacy and selectivity. © 2011 The Royal Society of Chemistry.

Bibliographic Details

László E. Kiss; Humberto S. Ferreira; Alexandre Beliaev; David A. Learmonth; Leonel Torrão; Maria João Bonifácio

Royal Society of Chemistry (RSC)

Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics; Chemistry

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