Reactions of metallodrugs with proteins: Selective binding of phosphane-based platinum(ii) dichlorides to horse heart cytochrome c probed by ESI MS coupled to enzymatic cleavage
Metallomics, ISSN: 1756-591X, Vol: 3, Issue: 10, Page: 987-990
2011
- 10Citations
- 9Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations10
- Citation Indexes10
- 10
- CrossRef9
- Captures9
- Readers9
Article Description
Reactions of cytotoxic platinum drugs with proteins are attracting growing attention for their relevant biological implications. We report here on the reactions of two cis-diphosphane platinum(ii) dichlorides (namely cis-bis(trimethylphosphane) platinum(ii) dichloride and cis- bis(triethylphosphane) platinum(ii) dichloride) with horse heart cytochrome c (cyt c) monitored through advanced ESI MS methods coupled to enzymatic digestion. A remarkable selectivity in terms of adduct stoichiometry is highlighted and the specific metal binding sites are localised on the protein surface. © 2011 The Royal Society of Chemistry.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=80053618796&origin=inward; http://dx.doi.org/10.1039/c1mt00069a; http://www.ncbi.nlm.nih.gov/pubmed/21947338; https://academic.oup.com/metallomics/article/3/10/987-990/6016212; https://dx.doi.org/10.1039/c1mt00069a; https://academic.oup.com/metallomics/article-abstract/3/10/987/6016212?redirectedFrom=fulltext
Oxford University Press (OUP)
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