Unlabeled multi tumor marker detection system based on bioinitiated light addressable potentiometric sensor
Analyst, ISSN: 1364-5528, Vol: 137, Issue: 16, Page: 3806-3813
2012
- 29Citations
- 22Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations29
- Citation Indexes29
- 29
- CrossRef25
- Captures22
- Readers22
- 22
Article Description
Multi biomarkers' assays are of great significance in clinical diagnosis. A label-free multi tumor markers' parallel detection system was proposed based on a light addressable potentiometric sensor (LAPS). Arrayed LAPS chips with basic structure of SiN-SiO-Si were prepared on silicon wafers, and the label-free parallel detection system for this component was developed with user friendly controlling interfaces. Then the l-3,4-dihydroxyphenyl-alanine (l-Dopa) hydrochloric solution was used to initiate the surface of LAPS. The l-Dopa immobilization state was investigated by the theoretical calculation. l-Dopa initiated LAPS' chip was biofunctionalized respectively by the antigens and antibodies of four tumor markers, α-fetoprotein (AFP), carcinoembryonic antigen (CEA), cancer antigen 19-9 (CA19-9) and Ferritin. Then unlabeled antibodies and antigens of these four biomarkers were detected by the proposed detection systems. Furthermore physical and measuring principles in this system were described, and qualitative understanding for experimental data were given. The measured response ranges were compared with their clinical cutoff values, and sensitivities were calculated by OriginLab. The results indicate that this bioinitiated LAPS based label-free detection system may offer a new choice for the realization of unlabeled multi tumor markers' clinical assay. © 2012 The Royal Society of Chemistry.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84863960183&origin=inward; http://dx.doi.org/10.1039/c2an35188a; http://www.ncbi.nlm.nih.gov/pubmed/22768391; https://xlink.rsc.org/?DOI=c2an35188a; https://dx.doi.org/10.1039/c2an35188a; https://pubs.rsc.org/en/content/articlelanding/2012/an/c2an35188a
Royal Society of Chemistry (RSC)
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