PlumX Metrics
Embed PlumX Metrics

Mass spectrometric identification and characterization of new toremifene metabolites in human urine by liquid chromatography quadrupole/time-of-flight tandem mass spectrometry (LC-QTOFMS)

Analytical Methods, ISSN: 1759-9660, Vol: 4, Issue: 2, Page: 439-443
2012
  • 4
    Citations
  • 0
    Usage
  • 23
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    4
    • Citation Indexes
      4
  • Captures
    23

Article Description

Urine samples after oral administration of toremifene were investigated by liquid chromatography quadrupole time-of-flight tandem mass spectrometry (LC-QTOFMS) with accurate mass measurement. Two new metabolites were detected in positive full scan and targeted MS/MS experiments and their chemical structures were characterized as: 3-methoxy-4,4′-dihydroxy-toremifene and 4-hydroxy-N-oxide-toremifene. As the two metabolites could be detected in all urine samples during one week after intake, they should be potential biomarkers for monitoring the oral administration of toremifene in doping analysis. © The Royal Society of Chemistry 2012.

Bibliographic Details

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know