Mass spectrometric identification and characterization of new toremifene metabolites in human urine by liquid chromatography quadrupole/time-of-flight tandem mass spectrometry (LC-QTOFMS)
Analytical Methods, ISSN: 1759-9660, Vol: 4, Issue: 2, Page: 439-443
2012
- 4Citations
- 23Captures
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Article Description
Urine samples after oral administration of toremifene were investigated by liquid chromatography quadrupole time-of-flight tandem mass spectrometry (LC-QTOFMS) with accurate mass measurement. Two new metabolites were detected in positive full scan and targeted MS/MS experiments and their chemical structures were characterized as: 3-methoxy-4,4′-dihydroxy-toremifene and 4-hydroxy-N-oxide-toremifene. As the two metabolites could be detected in all urine samples during one week after intake, they should be potential biomarkers for monitoring the oral administration of toremifene in doping analysis. © The Royal Society of Chemistry 2012.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84863135087&origin=inward; http://dx.doi.org/10.1039/c2ay05702f; https://xlink.rsc.org/?DOI=C2AY05702F; http://xlink.rsc.org/?DOI=C2AY05702F; http://pubs.rsc.org/en/content/articlepdf/2012/AY/C2AY05702F; https://dx.doi.org/10.1039/c2ay05702f; https://pubs.rsc.org/en/content/articlelanding/2012/ay/c2ay05702f
Royal Society of Chemistry (RSC)
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