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Inter-chain acyl transfer reaction in a peptide six-helical bundle: A chemical method for regulating the interaction between peptides or proteins

Chemical Communications, ISSN: 1364-548X, Vol: 48, Issue: 36, Page: 4320-4322
2012
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An inter-helical acyl transfer specifically occurred between the C-and N-peptides of HIV gp41 after assembly of the six-helical bundle (6HB), forming an inter-helical covalent bond that greatly enhanced 6HB stability. In the reaction, the C-peptide was modified as an acyl donor, and the N-peptide served as an acyl acceptor. © 2012 Royal Society of Chemistry.

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