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Synthesis and asymmetric hydrogenation of (3E)-1-benzyl-3-[(2-oxopyridin-1(2H)-yl)methylidene]piperidine-2,6-dione

Chemical Communications, ISSN: 1364-548X, Vol: 48, Issue: 98, Page: 11978-11980
2012
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Article Description

The synthesis of (3E)-1-benzyl-3-[(2-oxopyridin-1(2H)-yl)methylidene]piperidine-2,6-dione 4 from N-benzylglutarimide was achieved in three steps. The asymmetric hydrogenation of 4 gave either the product of partial reduction (10) or full reduction (13), depending on the catalyst which was employed, in high ee in each case. Attempts at asymmetric transfer hydrogenation (ATH) of 4 resulted in formation of a racemic product. © 2012 The Royal Society of Chemistry.

Bibliographic Details

Bisset, Alexander A; Shiibashi, Akira; Desmond, Jasmine L; Dishington, Allan; Jones, Teyrnon; Clarkson, Guy J; Ikariya, Takao; Wills, Martin

Royal Society of Chemistry (RSC)

Materials Science; Chemical Engineering; Chemistry

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