Effects of a PEG additive on the biomolecular interactions of self-assembled dendron nanostructures
Organic and Biomolecular Chemistry, ISSN: 1477-0520, Vol: 10, Issue: 42, Page: 8403-8409
2012
- 12Citations
- 25Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations12
- Citation Indexes12
- CrossRef12
- 12
- Captures25
- Readers25
- 25
Article Description
The ability of self-assembling multivalent DNA-binding dendrons to interact with biological targets is modified by co-assembly with two novel low-molecular-weight cholesterol-functionalised PEG units, one based on triethylene glycol (Chol-PEG-3) and one on an octaethylene glycol (Chol-PEG-8). The addition of either PEG lipid affected the co-assembled nanostructure surface charge and size in different ways depending on the structure of the self-assembling DNA-binding dendron. Co-assembly with Chol-PEG-8 enhanced DNA binding, while Chol-PEG-3 inhibited it. Insertion of Chol-PEG-8 into the aggregates modified their ability to cross a model mucus layer, the details of which can be understood in terms of a balance between the mucoadhesivity due to the surface charge of the nanoscale aggregates and that due to the PEG groups. This study demonstrates that the interaction of nanoscale assemblies with biological systems depends on a number of different factors in a sometimes unpredictable way. Given how simply multiple building blocks can be combined by self-assembly, we conclude that self-assembled multivalent systems have great potential for optimisation to maximise their biological and clinical activity. © 2012 The Royal Society of Chemistry.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84867379858&origin=inward; http://dx.doi.org/10.1039/c2ob26584b; http://www.ncbi.nlm.nih.gov/pubmed/23032349; https://xlink.rsc.org/?DOI=c2ob26584b; https://dx.doi.org/10.1039/c2ob26584b; https://pubs.rsc.org/en/content/articlelanding/2012/ob/c2ob26584b
Royal Society of Chemistry (RSC)
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