The effect of a fluorinated cholesterol derivative on the stability and physical properties of cationic DNA vectors
Soft Matter, ISSN: 1744-683X, Vol: 9, Issue: 2, Page: 401-409
2013
- 17Citations
- 14Captures
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Article Description
Liposomes of the cationic lipid DOTAP (1,2-dioleoyl-3-trimethylammonium- propane) and the fluorinated cholesterol derivative heptafluorocholesterol (F7-CHOL) were tested at the molar ratio of 1 : 1 for DNA compaction and transfection. Their properties were correlated with the characteristics of the well-known system, DOTAP and cholesterol (CHOL). The mass lipid-DNA (L/D) ratios at the isoelectric point were within the ranges 3-4 for DOTAP:CHOL and 4-5 for DOTAP:F7-CHOL, as determined by electrophoretic mobility measurements. These results and the ethidium bromide fluorescence intercalation assays confirmed that more DOTAP:F7-CHOL liposomes are needed to compact the same amount of DNA as DOTAP:CHOL. The phase diagrams of aggregation and re-entrant condensation phenomena obtained by phenomenological theory support this conclusion and also establish that the liposome-DNA binding is stronger in the case of the DOTAP:F7-CHOL-DNA system. The stability rates of both liposomes in the presence of DNA and their transfection efficiencies were similar, which support the application of heptafluorocholesterol as a helper lipid in cationic liposomes for DNA delivery. © The Royal Society of Chemistry 2013.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84870908453&origin=inward; http://dx.doi.org/10.1039/c2sm27236a; https://xlink.rsc.org/?DOI=C2SM27236A; http://xlink.rsc.org/?DOI=C2SM27236A; http://pubs.rsc.org/en/content/articlepdf/2013/SM/C2SM27236A; https://dx.doi.org/10.1039/c2sm27236a; https://pubs.rsc.org/en/content/articlelanding/2013/sm/c2sm27236a
Royal Society of Chemistry (RSC)
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