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Organocatalyzed asymmetric vinylogous Michael addition of α,β-unsaturated γ-butyrolactam

Chemical Communications, ISSN: 1364-548X, Vol: 49, Issue: 81, Page: 9329-9331
2013
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Article Description

Highly efficient asymmetric vinylogous 1,6-Michael addition of α,β-unsaturated γ-butyrolactam to 3-methyl-4-nitro-5-alkenyl-isoxazoles and Michael addition to trichloromethyl ketones by using a chiral quinine-derived squaramide organocatalyst were described, giving products with high diastereo- and enantioselectivities (up to >25 : 1 dr and 96% ee). © 2013 The Royal Society of Chemistry.

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