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Membrane destabilization by monomeric hIAPP observed by imaging fluorescence correlation spectroscopy

Chemical Communications, ISSN: 1364-548X, Vol: 49, Issue: 80, Page: 9155-9157
2013
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Article Description

Monomeric hIAPP significantly destabilizes both model and live cell membranes by increasing membrane fluidity. This interaction with membranes happens via carpet formation followed by lipid extraction in a concentration dependent manner and thus we propose that hIAPP aggregation prior to membrane interaction may not be necessary for its cytotoxicity. © 2013 The Royal Society of Chemistry.

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