PlumX Metrics
Embed PlumX Metrics

Synthetic modification of salinomycin: Selective O-acylation and biological evaluation

Chemical Communications, ISSN: 1364-548X, Vol: 49, Issue: 85, Page: 9944-9946
2013
  • 56
    Citations
  • 0
    Usage
  • 39
    Captures
  • 0
    Mentions
  • 49
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    56
  • Captures
    39
  • Social Media
    49
    • Shares, Likes & Comments
      49
      • Facebook
        49

Article Description

Salinomycin has found renewed interest as an agent for prevention of cancer recurrence through selectively targeting cancer stem cells. Strategies for generation of improved salinomycin analogs by individual modification of its hydroxyl groups are presented. An evaluation of the dose-response effects of the resulting library on breast cancer cell lines shows that acylation of the C20 hydroxyl can be used to improve IC values down to one fifth that of salinomycin. © 2013 The Royal Society of Chemistry.

Bibliographic Details

Borgström, Björn; Huang, Xiaoli; Pošta, Martin; Hegardt, Cecilia; Oredsson, Stina; Strand, Daniel

Royal Society of Chemistry (RSC)

Materials Science; Chemical Engineering; Chemistry

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know