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Palladium-catalyzed intermolecular [3 + 2] carbocyclization of alkynols and propiolates: An efficient entry to halo-cyclopentadienes

Chemical Communications, ISSN: 1364-548X, Vol: 50, Issue: 7, Page: 846-848
2014
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Article Description

A novel and efficient Pd-catalyzed intermolecular [3 + 2] carbocyclization of alkynols and electron-deficient alkynes for the synthesis of halo-cyclopentadienes (Cps) has been developed. The present protocol employs simple propargyl alcohols as the C3 group to participate in the cyclization reaction, providing a highly convenient and atom-economical entry to the halo-cyclopentadiene framework. © 2013 The Royal Society of Chemistry.

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