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Ga chelating bioorthogonal tetrazine polymers for the multistep labeling of cancer biomarkers

Chemical Communications, ISSN: 1364-548X, Vol: 50, Issue: 40, Page: 5215-5217
2014
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Article Description

We have developed a Ga metal chelating bioorthogonal tetrazine dextran probe that is highly reactive with trans-cyclooctene modified monoclonal antibodies for multistep imaging applications. Confocal microscopy and positron emission tomography (PET) were used to characterize the dextran probe in vitro and in vivo. © 2014 Partner Organisations.

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