Trisubstitution of pyridine through sequential and regioselective palladium cross-coupling reactions affording analogs of known GPR54 antagonists
RSC Advances, ISSN: 2046-2069, Vol: 3, Issue: 26, Page: 10296-10300
2013
- 10Citations
- 15Captures
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Article Description
Because of their large spectrum of applications, poly-functionalized pyridines remain an attractive challenge in modern organic chemistry. We describe the poly-functionalization of halopyridines through a series of sequential and regioselective palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Sonogashira and Buchwald-Hartwig reactions). This strategy was applied to the synthesis of several analogs of single non-peptidic known GPR54 antagonists. © The Royal Society of Chemistry 2013.
Bibliographic Details
Royal Society of Chemistry (RSC)
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