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Addressable droplet microarrays for single cell protein analysis

Analyst, ISSN: 1364-5528, Vol: 139, Issue: 21, Page: 5367-5374
2014
  • 12
    Citations
  • 0
    Usage
  • 37
    Captures
  • 0
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  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

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Article Description

Addressable droplet microarrays are potentially attractive as a way to achieve miniaturised, reduced volume, high sensitivity analyses without the need to fabricate microfluidic devices or small volume chambers. We report a practical method for producing oil-encapsulated addressable droplet microarrays which can be used for such analyses. To demonstrate their utility, we undertake a series of single cell analyses, to determine the variation in copy number of p53 proteins in cells of a human cancer cell line.

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