Complete switch from α-2,3- to α-2,6-regioselectivity in Pasteurella dagmatis β-d-galactoside sialyltransferase by active-site redesign
Chemical Communications, ISSN: 1364-548X, Vol: 51, Issue: 15, Page: 3083-3086
2015
- 42Citations
- 49Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations42
- Citation Indexes42
- 42
- CrossRef41
- Captures49
- Readers49
- 49
Article Description
Structure-guided active-site redesign of a family GT-80 β-d-galactoside sialyltransferase (from Pasteurella dagmatis) to change enzyme regioselectivity from α-2,3 in the wild type to α-2,6 in a P7H-M117A double mutant is reported. Biochemical data for sialylation of lactose together with protein crystal structures demonstrate highly precise enzyme engineering.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84930006385&origin=inward; http://dx.doi.org/10.1039/c4cc09772f; http://www.ncbi.nlm.nih.gov/pubmed/25619424; http://xlink.rsc.org/?DOI=C4CC09772F; http://pubs.rsc.org/en/content/articlepdf/2015/CC/C4CC09772F; https://xlink.rsc.org/?DOI=C4CC09772F; https://dx.doi.org/10.1039/c4cc09772f; https://pubs.rsc.org/en/content/articlelanding/2015/cc/c4cc09772f
Royal Society of Chemistry (RSC)
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