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Photo-controlled targeted intracellular delivery of both nitric oxide and singlet oxygen using a fluorescence-trackable ruthenium nitrosyl functional nanoplatform

Chemical Communications, ISSN: 1364-548X, Vol: 51, Issue: 13, Page: 2555-2558
2015
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Article Description

A multifunctional nitric oxide (NO) delivery nanoplatform that combines functionalities of target directing, fluorescence tracking, and photo-controlled target attacking was developed. The {Ru-NO@TiO NPs} nanoplatform selectively targeted folate-receptor over-expressed cancer cells while being simultaneously traced based on its inherent fluorescence. Intracellular localized NO and singlet oxygen were produced on demand by controlled visible light illumination, producing a synergistic cytotoxic effect to cancer cells. This journal is

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