Design, synthesis and molecular docking of novel bipyrazolyl thiazolone scaffold as a new class of antibacterial agents
MedChemComm, ISSN: 2040-2511, Vol: 5, Issue: 10, Page: 1555-1562
2014
- 37Citations
- 12Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
A new series of bipyrazolyl thiazolone hybrids were designed based on molecular hybridization technique. All the synthesized compounds were characterized by elemental analysis and various spectroscopic methods. They were tested for their in vitro antibacterial activity against two Gram-positive and two Gram-negative bacteria as well as E. coli FabH using Kanamycin B and Penicillin G as the standard drugs. Of the compounds studied, compound 10c (IC50 = 2.1 μM) showed the most effective E. coli FabH inhibitory activity as compared to other members of the series. The molecular docking study indicated that compound 10c was found nicely bound into the active site of E. coli FabH with hydrogen bonds, π-π and π-cation interactions having minimum binding energy ΔGb = -52.27 kcal mol-1. This journal is
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84907811028&origin=inward; http://dx.doi.org/10.1039/c4md00238e; http://xlink.rsc.org/?DOI=C4MD00238E; http://pubs.rsc.org/en/content/articlepdf/2014/MD/C4MD00238E; https://xlink.rsc.org/?DOI=C4MD00238E; https://dx.doi.org/10.1039/c4md00238e; https://pubs.rsc.org/en/content/articlelanding/2014/md/c4md00238e
Royal Society of Chemistry (RSC)
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