In vitro osteogenesis of mesenchymal stem cells promoted by the release of La and SiO from sheet-shaped lanthanum dropped hexagonal mesoporous silicon
RSC Advances, ISSN: 2046-2069, Vol: 4, Issue: 49, Page: 25948-25956
2014
- 4Citations
- 3Captures
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Article Description
In this study, in vitro osteogenesis was successfully promoted in mouse mesenchymal stem cells (BMSCs) by the release of La and SiO from a sheet-shaped lanthanum dropped hexagonal mesoporous silica (La-HMS). In comparison with previous nano-sphere shaped La-HMS, the sheet-shaped morphology was similar to the inorganic component of bone, which could provide better toughness during bone repair and regeneration. The successful incorporation of La into the HMS was confirmed by the results of XRD and ICP-AES. In vitro proliferation was verified by CCK-8 and osteogenesis was verified by an alkaline phosphatase (ALP) activity assay, ALP staining, a calcium secretion assay and collagen secretion analysis. Considering the renewable source and highly proliferative nature of BMSCs, the achievement of engineered BMSC osteogenesis with this La-HMS could allow new applications in major bone repair and regeneration. © the Partner Organisations 2014.
Bibliographic Details
Royal Society of Chemistry (RSC)
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